Date of Award

1-1-2011

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College/School/Department

Department of Biomedical Sciences

Content Description

1 online resource (xii, 137 pages) : PDF file, illustrations (some color)

Dissertation/Thesis Chair

Douglas Conklin

Committee Members

Conly Rieder, Erasmus Schneider, Andrew Aplin, Julio Aguirre-Ghiso

Keywords

anoikis, lumen, mammary, morphogenesis, p38, Breast, Protein kinases, Mitogen-activated protein kinases

Subject Categories

Cell Biology | Developmental Biology

Abstract

Breast tumors arise from preinvasive lesions consisting of abnormal epithelial cells that accumulate within the mammary duct. However, the initiating steps and underlying pathways leading to the formation of these early stages of breast carcinoma, such as ductal carcinoma in situ (DCIS), is not fully understood.

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