Date of Award
1-1-2011
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Chemistry
Content Description
1 online resource (viii, 111 pages) : illustrations (some color)
Dissertation/Thesis Chair
Jason R Shepard
Committee Members
Igor Lednev, Carla Theimer, Paul Toscano, Hua Shi
Keywords
Cells, Cytology, Cell transplantation
Subject Categories
Analytical Chemistry | Biochemistry
Abstract
In the past decade, the shift from whole cell population analyses towards single cell measurement methods and techniques is based on experimental results that reveal significant levels of non-genetic heterogeneity in clonal cell populations. This heterogeneity manifests in multiple aspects of cell activity and is, in part, a result of stochastic noise in processes leading to gene expression, namely transcription and translation. The growing understanding of this occurrence has led to the development of methods to monitor and analyze heterogeneity for a more thorough description of cell populations and overall activity.
Recommended Citation
Walling, Maureen Ann, "Single cell analysis for the characterization of cell populations using a live cell array" (2011). Legacy Theses & Dissertations (2009 - 2024). 473.
https://scholarsarchive.library.albany.edu/legacy-etd/473