Regulation of the aryl hydrocarbon receptor and the signal transducer and activator of transcription 1 by long-term estrogen exposure in breast carcinoma cells

Author

Neal Englert, University at Albany, State University of New YorkFollow

Date of Award

1-1-2011

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College/School/Department

Department of Environmental Health Sciences

Content Description

1 online resource (xv, 279 pages) : illustrations (some color)

Dissertation/Thesis Chair

David C. Spink

Committee Members

Xinxin Ding, Robert Jansing, Jun Gu, George Plopper

Keywords

Breast, Estrogen

Subject Categories

Cell Biology | Molecular Biology | Toxicology

Abstract

The risk of developing breast cancer is known to be associated with a woman's lifetime exposure to estrogens, both endogenous and exogenous. Increased exposure to estrogens stimulates cellular proliferation, which is a widely accepted theory of estrogen receptor positive mammary carcinogenesis. The molecular mechanisms of gene expression regulation in response to long-term estrogen exposure (LTEE) of MCF-7 breast cancer cells were addressed in this study, with a focus on the aryl hydrocarbon receptor (AHR) and signal transducer and activator of transcription 1 (STAT1).

Recommended Citation

Englert, Neal, "Regulation of the aryl hydrocarbon receptor and the signal transducer and activator of transcription 1 by long-term estrogen exposure in breast carcinoma cells" (2011). Legacy Theses & Dissertations (2009 - 2024). 337.
https://scholarsarchive.library.albany.edu/legacy-etd/337