Date of Award
1-1-2019
Language
English
Document Type
Master's Thesis
Degree Name
Master of Science (MS)
College/School/Department
Department of Epidemiology and Biostatistics
Program
Epidemiology
Content Description
1 online resource (ii, 19 pages) : illustrations (some color)
Dissertation/Thesis Chair
Mark H Kuniholm
Committee Members
Allison Appleton
Keywords
Carotid, CVD, HCV, HIV, lesion, PCSK9, HIV-positive women, Hepatitis C virus, Carotid artery, Protein precursors, Hepacivirus, Carotid Artery Diseases, Protein Precursors
Subject Categories
Epidemiology
Abstract
Background: Increase in risk for coronary artery disease (CAD) is a well-documented for HIV-infected (HIV+) populations. A precursor of cardiovascular events in HIV+ populations are non-calcified plaque (lesion) formations and can be associated with arterial inflammation, monocyte aggregation and dendritic cell activation. PCSK9 a known modulator of LDL cholesterol, has also been shown to contribute to inflammation, dendritic cell activation, monocyte aggregation and potentially plaque formations.
Recommended Citation
Searles, Michael Patrick, "Association of serum PCSK9 with carotid artery thickness and carotid lesions in women with HIV and hepatitis C virus" (2019). Legacy Theses & Dissertations (2009 - 2024). 2376.
https://scholarsarchive.library.albany.edu/legacy-etd/2376