Date of Award
1-1-2013
Language
English
Document Type
Master's Thesis
Degree Name
Master of Science (MS)
College/School/Department
Department of Chemistry
Content Description
1 online resource (vii, 70 pages) : illustrations (some color)
Dissertation/Thesis Chair
Daniele Fabris
Committee Members
Alexander Shekhtman
Keywords
Mass Spectrometry, Post-Transcriptional Modification, RNA, HIV (Viruses), Mass spectrometry, Nucleosides
Subject Categories
Chemistry
Abstract
The genomic structure of the human immunodeficiency virus type 1 (HIV-1) has proven difficult to examine by traditional high-resolution techniques. Structural probing and in silico modeling have been turned to the task instead. Computer models are only as robust as the data used to create them. A number of techniques were explored in this investigation to expand the utility of in silico modeling as it relates to HIV-1: the study of nucleoside modifications, and the probing of in vivo conformations of the 5'-untranslated region (5'-UTR) by cross-linking and affinity capture.
Recommended Citation
Quinn, Ryan, "From whole-cell to compartment- and class-specific analysis of RNA post-transcriptional modifications" (2013). Legacy Theses & Dissertations (2009 - 2024). 988.
https://scholarsarchive.library.albany.edu/legacy-etd/988