Date of Award

1-1-2009

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College/School/Department

Department of Nanoscale Science and Engineering

Program

Nanoscale Engineering

Content Description

1 online resource (viii, 111 pages) : illustrations (chiefly color)

Dissertation/Thesis Chair

Anand Gadre

Committee Members

James Castracane, Nathaniel Cady, Michael Carpenter, Lauren Brasile, Makarand Paranjape

Keywords

glucose oxidase, kidney transplantation, MEMS, microfabracation, redox mediator, sensors, Kidneys, Blood glucose monitoring, Oxidation-reduction reaction, Biosensors

Subject Categories

Biomedical Engineering and Bioengineering | Nanoscience and Nanotechnology | Systems Science

Abstract

The major limiting factor in kidney clinical transplantation is the shortage of transplantable organs. The current inability to distinguish viability from non-viability on a prospective basis represents a major obstacle in any attempt to expand organ donor criteria. Consequently, a way to measure and monitor a relevant analyte to assess kidney viability is needed. For the first time, the initial development and characterization of a metabolic microsensor to assess kidney viability is presented. The rate of glucose consumption appears to serve as an indicator of kidney metabolism that may distinguish reversible from irreversible kidney damage. The proposed MetaSense (Metabolic Sensor) microdevice would replace periodic laboratory diagnosis tests with a continuous monitor that provides real-time data on organ viability.

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