Date of Award
1-1-2013
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Biological Sciences
Content Description
1 online resource (x, 120 pages) : illustrations (some color)
Dissertation/Thesis Chair
Ing-Nang Wang
Committee Members
Tom Caraco, Jim Bull, Cara Pager
Keywords
Bacteriophage therapy, Drosophila melanogaster, experimental evolution, Pseudomonas aeruginosa, Bacteriophages
Subject Categories
Biology
Abstract
Due to the increase in antibiotic resistant bacteria, there has been renewed interest in using bacteriophage to treat bacterial infections (phage therapy). This body of work examined different aspects related to the interaction between bacteria and phage within a host using the system of Drosophila melanogaster infected with Pseudomonas aeruginosa, which is then treated with lytic bacteriophage. Using this system four specific areas were addressed: I) How in vitro phage life history traits may be predictive of in vivo therapeutic efficacy, II) How the in vivo phage/bacteria dynamics differ for two different phages throughout the course of infection, III) How modification of phage life history traits alters phage therapeutic ability and IV) The variable costs of phage resistance within P. aeruginosa.
Recommended Citation
Lindberg, Heather, "Phage life history traits : regulation of Pseudomonas aeruginosa and evolution of phage resistance within the Drosophila melanogaster host environment" (2013). Legacy Theses & Dissertations (2009 - 2024). 930.
https://scholarsarchive.library.albany.edu/legacy-etd/930