Date of Award

1-1-2013

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College/School/Department

Department of Epidemiology and Biostatistics

Program

Biostatistics

Content Description

1 online resource (xiii, 134 pages) : illustrations (some color)

Dissertation/Thesis Chair

A. Gregory DiRienzo

Committee Members

Perry F Smith, Recai Yucel

Keywords

Dimension reduction, HIV-1, Nonlikelihood based methods, Polychotomous models, Survival analysis, HIV (Viruses), Drug resistance, Survival analysis (Biometry)

Subject Categories

Biostatistics

Abstract

Although treatment for human immunodeficiency virus type-1 (HIV-1) has undergone drastic change and morbidity and mortality has decreased over time, the development of drug-resistant HIV-1 is of concern for the long-term antiretroviral treatment of infected individuals. Drug-resistant virus is known to manifest with potentially complex mutational patterns in the HIV-1 genotype sequence and is associated with decreased response to therapy. Resistance occurs either as a result of development of mutations in the viral genome under selective drug pressure or as a result of naturally occurring polymorphisms. The most effective treatment methods are still debated at this time; however, current treatment methods are focused on drug cocktails and the importance of first-line regimens. This emphasizes the need for rapid discovery of virolgic failure through clinical tests and statistical methods for interpreting genotypic resistance patterns.

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