Date of Award
1-1-2013
Language
English
Document Type
Master's Thesis
Degree Name
Master of Science (MS)
College/School/Department
Department of Chemistry
Content Description
1 online resource (xi, 91 pages) : illustrations (some color)
Dissertation/Thesis Chair
Carla Theimer
Keywords
gene expression control, histone stem-loop, microRNA, stem-loop binding protein, Non-coding RNA, Messenger RNA, Genetic regulation
Subject Categories
Biochemistry
Abstract
In the past decade, microRNAs (miRNAs) have become a hot topic in biochemical research. These very short ~ 22 nucleotide strands of RNA have been recognized as a functional RNA group and found to play a key role in mediating gene regulation along with RNA-binding proteins (RBPs). For example, by binding to the histone stem-loop (HSL) region of the target mRNA, normally in the 3'- untranslated region (UTR), gene expression can either be activated or deactivated for up or down regulation of the gene product. The majority of miRNAs have been found to down regulate gene expression upon binding to the 3'- UTR of an mRNA, but potentially miRNAs can also act as trigger up regulation of gene products in the cell.
Recommended Citation
Bazinet, Christine, "The sxRNA platform : biophysical characterization of trans-acting RNA switches for gene expression control" (2013). Legacy Theses & Dissertations (2009 - 2024). 829.
https://scholarsarchive.library.albany.edu/legacy-etd/829