Date of Award
1-1-2012
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Biomedical Sciences
Content Description
1 online resource (xiii, 185 pages) : color illustrations.
Dissertation/Thesis Chair
Randall H Morse
Committee Members
M. Joan Curcio, Steven D Hanes, Richard S Zitomer, Thomas J Begley
Keywords
Saccharomyces cerevisiae, Transcription factors, Genetic transcription, Chromatin
Subject Categories
Genetics | Molecular Biology
Abstract
Abf1 and Rap1 are functionally similar general regulatory factors (GRFs) found in Saccharomyces cerevisiae . Abf1, in its role as a transcriptional activator, exerts a memory effect on some genes under its control. This effect results in transcription levels remaining steady when Abf1 dissociates from its binding site in a conditional mutant. In contrast, Rap1 fails to elicit the same effect on its regulatory targets. Transcriptional memory effects have been observed in many fields of study, including immunology, cancer, and stem cells, and conservation of transcription machinery will allow studies in yeast to be applied to higher organisms.
Recommended Citation
Paul, Emily Leigh, "The role of chromatin and cofactors in the transcriptional memory effect exerted in Saccharomyces cerevisiae" (2012). Legacy Theses & Dissertations (2009 - 2024). 732.
https://scholarsarchive.library.albany.edu/legacy-etd/732