Date of Award
1-1-2012
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Biomedical Sciences
Content Description
1 online resource (xvi, 184 pages) : illustrations (some color)
Dissertation/Thesis Chair
Ben G Szaro
Committee Members
John Schmidt, Albert Millis, Min-Ho Lee
Keywords
axonogenesis, CNS regeneration, cytoskeleton, hnRNP K, optic nerve, post-transcriptional regulation, Axons, RNA-protein interactions, Nervous system, Genetic regulation, Genetic transcription, Xenopus laevis
Subject Categories
Biology | Developmental Biology | Neuroscience and Neurobiology
Abstract
Coordinated synthesis and assembly of the cytoskeletal network contribute significantly to morphological changes during axon outgrowth. Previous studies demonstrated that heterogeneous ribonucleoprotein K (hnRNP K), an RNA binding protein, binds to the 3'-untranslated regions of all neurofilament triplet subunits, the most abundant components of the axonal cytoskeleton. These findings raised the hypothesis that hnRNP K post-transcriptionally mediates the coordinated expression of axonal cytoskeletal components. In my thesis, I test this hypothesis during both axonal development and regeneration.
Recommended Citation
Liu, Yuanyuan, "The role of an RNA binding protein hnRNP K during axon development and regeneration in Xenopus laevis" (2012). Legacy Theses & Dissertations (2009 - 2024). 680.
https://scholarsarchive.library.albany.edu/legacy-etd/680