Date of Award

1-1-2011

Language

English

Document Type

Master's Thesis

Degree Name

Master of Science (MS)

College/School/Department

Department of Chemistry

Content Description

1 online resource (ix, 88 pages) : illustrations (some color)

Dissertation/Thesis Chair

Carla A. Theimer

Committee Members

Alexander Shekhtman

Keywords

Nucleic acids, Binding sites (Biochemistry), Physical biochemistry, DNA-protein interactions

Subject Categories

Chemistry

Abstract

Nucleic acids are the biomolecules that encodes all the genetic information necessary for cellular metabolism. Binding of small molecules to DNA or RNA can alter their structures; perturb their functions as well as interactions with proteins and other ligands. This thesis focuses on the biophysical study of the interactions of three planar compounds with TAR 32 DNA (32 ntds DNA in HIV-1 LTR, Figure. The purpose for this study is to understand the binding modes of some of the potential drug target compounds, which will be useful for future rational drug design strategies.

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