Date of Award
1-1-2012
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Biological Sciences
Content Description
1 online resource (x, 148 pages) : PDF file, illustrations (some color)
Dissertation/Thesis Chair
Min H Lee
Committee Members
Richard S Zitomer, Hua Shi, Douglas S Conklin
Keywords
RNA-protein interactions, Genetic transcription, Messenger RNA, Caenorhabditis elegans, Germ cells
Subject Categories
Biology
Abstract
Considering the general suppression of transcription during late oogenesis and early embryo development, post-transcriptional control of maternal mRNAs by RNA binding proteins emerges as an important mechanism in controlling late oogenesis and early embryo development. The C. elegans germline offers an ideal system to understand such processes. GLD-1 (GermLine Development defective) is a maxi-KH motif containing RNA binding protein, which controls many different stages during the C. elegans germline development from decision over germ cell proliferation vs. meiosis entry to production of mature gametes, suggesting that GLD-1 likely controls many mRNA targets. gld-1 mutants have variable germline defects, the major defect being an ectopic proliferation of germ cells leading to the germline tumor.
Recommended Citation
Doh, Jung Hoon, "The C. elegans RNA-binding protein GLD-1 recognizes sequence, structure and context information to repress translation of its mRNA targets" (2012). Legacy Theses & Dissertations (2009 - 2024). 547.
https://scholarsarchive.library.albany.edu/legacy-etd/547