Date of Award

1-1-2011

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College/School/Department

Department of Chemistry

Content Description

1 online resource (xxi, 140 pages) : illustrations (some color)

Dissertation/Thesis Chair

Igor K Lednev

Committee Members

Rabi A Musah, Jayanti Pande, Kevin H Knuth

Keywords

Amyloid fibrils, Body fluids, Chemometrics, Forensic identification, Polarized Raman spectroscopy, Raman spectroscopy, Chemistry, Forensic

Subject Categories

Analytical Chemistry | Biochemistry

Abstract

This work is dedicated to the development and application of advanced statistical methods for biochemical and forensic applications of Raman spectroscopy. We developed a new concept of multidimensional Raman signatures for forensic identification of body fluid traces, which was successfully applied to the study of dried blood, semen, saliva, sweat and vaginal fluid stains. Several alternative advanced chemometric techniques were also successfully tested for the problems of pure body fluids discrimination and mixture analysis. Studies of body fluid mixtures with low blood and semen concentrations indicated that the detection limit of a minor contributor was as low as a few percent.

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