Date of Award

8-1-2022

Language

English

Document Type

Master's Thesis

Degree Name

Master of Science (MS)

College/School/Department

Department of Biological Sciences

Content Description

1 online resource (v, 28 pages) : illustrations (some color)

Dissertation/Thesis Chair

Bijan Dey

Committee Members

Melinda Larsen

Keywords

Myogenesis, Methylation, RNA editing

Subject Categories

Biology | Developmental Biology | Molecular Biology

Abstract

Myogenesis involves skeletal muscle stem cells (MuSCs) that produce and regenerate skeletal muscle during regular growth and repair. However, when this system fails to function normally, it can lead to musculoskeletal diseases like Duchenne Muscular Dystrophy (DMD). Therefore, it is important to study the molecular mechanisms behind this developmental process in order to seek therapies and solutions for these types of diseases. Our interest lies in the field of epitranscriptomics, which focuses on post-transcriptional ribonucleic acid (RNA) modifications, particularly N6-methyladenosine (m6A), which involves the addition of a methyl group to the adenosine nucleotide, a process that is mediated by the methyltransferase-like protein 3 (METTL3) enzyme. Little is known regarding the contribution of epitranscriptomics and m6A to the development of DMD. The goal of this library thesis is to review and analyze existing scientific literature to evaluate the regulatory role that the METTL3-catalyzed m6A modification plays in skeletal muscle development, regeneration, and disease for the purposes of identifying therapeutic opportunities.

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