Date of Award

1-1-2022

Language

English

Document Type

Master's Thesis

Degree Name

Master of Science (MS)

College/School/Department

Department of Biological Sciences

Content Description

1 online resource (iii, 59 pages)

Dissertation/Thesis Chair

Morgan A Sammons

Committee Members

ChangHwan Lee

Keywords

ATF4, Cellular Stress, P53, Transcription Factors, Gene expression, Gene regulatory networks, Stress (Physiology), p53 antioncogene

Subject Categories

Cell Biology

Abstract

Cellular stress is something that a cell deals with on a regular basis. Fortunately, there are several different mechanisms that are set in place in order to deal with them. Depending on the stress present in the cell there will be different stress response pathways that are activated in order to mitigate the stress or initiate cellular death mechanisms. Transcription factors (TFs) are key components within these pathways, and this will be the focus of this thesis. TFs within mammalian stress response pathways are tasked with the essential regulation of multiple genes within these pathways and are oftentimes linked with diseases when mutated. ATF4 and P53 are two central TFs that work within the Integrated Stress Response and DNA damage response pathways respectively. This thesis will highlight important aspects of gene regulation within cell stress pathways and highlight these two central TFs and their roles in stress response pathways.

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