Influenza A virus : pathogenesis and novel vaccines

Date of Award

1-1-2010

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College/School/Department

Department of Biomedical Sciences

Content Description

1 online resource (xiv, 192 leaves) : illustrations.

Dissertation/Thesis Chair

David E Wentworth

Committee Members

Kristen A Bernard, April D Burch, Todd A Gray, Paul S Masters, Sean M Philpott, Pei-Yong Shi, David E Wentworth

Keywords

Influenza Genomic Amplification, Live Attenuated Vaccine, Nonstructural Protein NS1, Pathogenic Determinant, Polymerase Basic Protein PB2, Temperature-Sensitive, Influenza A virus, Influenza vaccines, H1N1 influenza, Mice as laboratory animals, Influenza Vaccines

Subject Categories

Virology

Abstract

Influenza A viruses are important human and animal pathogens. They are antigenically classified into different subtypes based on the surface glycoproteins hemagglutin (H1-H16) and neuraminidase (N1-N9). All the subtypes have been isolated in avian species, and the H3N2 and H1N1 subtypes, which co-circulate with influenza B viruses in the human population, are responsible for the annual influenza epidemics that cause 250-500 million infections that result in 250,000-500,000 deaths.

Comments

Requested ProQuest takedown; no end date

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