Date of Award

5-1-2021

Language

English

Document Type

Master's Thesis

Degree Name

Master of Science (MS)

College/School/Department

Department of Chemistry

Content Description

1 online resource (vii, 71 pages) : illustrations (chiefly color)

Dissertation/Thesis Chair

Jeremy Feldblyum

Committee Members

Alan Chen

Keywords

Polymeric drug delivery systems, Drug delivery systems, Nanoparticles, Nanocapsules

Subject Categories

Chemistry

Abstract

Conventional drug delivery is associated with challenges such as low bioavailability, reduced half-life, nonspecific interactions, high immunogenicity, and degradation of drug before reaching the target. Modern drug delivery systems are designed to overcome the challenges of conventional drug delivery methods. Polymers play a crucial role in the development of modern drug delivery systems. Polymers form delivery vehicles that improve the therapeutic efficacy and reduce the side effects of a drug. Furthermore, it is possible to control the release of drug by using the delivery vehicles. Polymeric vehicles exist in different forms such as polymeric nanoparticles, hydrogels, and vesicles. Each form of the delivery vehicle offers unique advantages in terms of drug release, encapsulation efficiency, and ability to react the target. This thesis provides a review on challenges in conventional drug delivery methods, different polymeric drug delivery vehicles, their preparation methods, applications, and areas for improvement.

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