Date of Award
1-1-2020
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Biological Sciences
Content Description
1 online resource (ix, 99 pages) : illustrations (some color)
Dissertation/Thesis Chair
Gabriele Fuchs
Committee Members
Melinda Larsen, Cara Pager, Joseph Wade
Keywords
GYS1, IRES, RACK1, Ribosome heterogeneity, Translation, Translational control, Genetic translation, Ribosomes, Protein kinases, Genetic regulation, RNA viruses
Subject Categories
Biology | Molecular Biology | Virology
Abstract
Translation is a crucial mechanism for generating proteins to carry out cellular processes and for ensuring proper cell functions. Ribosomes are at the center of translation and are complex pieces of machinery. They consist of at least 80 core eukaryotic ribosomal proteins, which are conserved from prokaryotes, and four ribosomal RNAs (rRNAs): 18S, 28S, 5,8A 5S. In addition, numerous translation factors aid the ribosome in protein production. While ribosomes are typically described by these core features, they are known to exist in a heterogenous pool with variations in protein composition, modifications of rRNA, and an assortment of non-ribosomal proteins that can associate with the translation complex. This variety is thought to allow for preferential translation of subsets of mRNAs depending on RNA elements and their recruitment for certain translation factors.
Recommended Citation
Miller, Clare Margaret, "Regulation of gene expression through ribosome-associated proteins" (2020). Legacy Theses & Dissertations (2009 - 2024). 2521.
https://scholarsarchive.library.albany.edu/legacy-etd/2521
Included in
Biology Commons, Molecular Biology Commons, Virology Commons