Date of Award

1-1-2020

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College/School/Department

Department of Biological Sciences

Content Description

1 online resource (ix, 99 pages) : illustrations (some color)

Dissertation/Thesis Chair

Gabriele Fuchs

Committee Members

Melinda Larsen, Cara Pager, Joseph Wade

Keywords

GYS1, IRES, RACK1, Ribosome heterogeneity, Translation, Translational control, Genetic translation, Ribosomes, Protein kinases, Genetic regulation, RNA viruses

Subject Categories

Biology | Molecular Biology | Virology

Abstract

Translation is a crucial mechanism for generating proteins to carry out cellular processes and for ensuring proper cell functions. Ribosomes are at the center of translation and are complex pieces of machinery. They consist of at least 80 core eukaryotic ribosomal proteins, which are conserved from prokaryotes, and four ribosomal RNAs (rRNAs): 18S, 28S, 5,8A 5S. In addition, numerous translation factors aid the ribosome in protein production. While ribosomes are typically described by these core features, they are known to exist in a heterogenous pool with variations in protein composition, modifications of rRNA, and an assortment of non-ribosomal proteins that can associate with the translation complex. This variety is thought to allow for preferential translation of subsets of mRNAs depending on RNA elements and their recruitment for certain translation factors.

Download

Share

COinS