Date of Award
1-1-2020
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Biomedical Sciences
Content Description
1 online resource (xviii, 236 pages) : illustrations (some color)
Dissertation/Thesis Chair
Nicholas J Mantis
Committee Members
Kathleen McDonough, Joseph Wade, Todd Gray, Fitnat Yildiz
Keywords
Antibody, Cholera, Enteric, Immunity, Pathogen, Vibrio cholerae, Lipoprotein antibodies, Immunoglobulins, Intestinal absorption, Mice as laboratory animals
Subject Categories
Immunology of Infectious Disease | Microbiology | Molecular Biology
Abstract
The outer membrane (OM) of Gram-negative enteric pathogens like Vibrio cholerae is a barrier against host defense factors, as well as a sensor of physical and chemical stimuli that the bacteria encounter in the gastrointestinal tract. The OM is also the primary target of the mucosal immune response, which consists of secretory antibodies primarily directed against lipopolysaccharide (LPS). ZAC-3 is a monoclonal antibody (MAb) that targets the conserved core/lipid A region of LPS of the pandemic V. cholerae O1 serotype. In a neonatal mouse model, passively administered ZAC-3 IgG has been shown to reduce the ability of V. cholerae to colonize the intestinal epithelium.
Recommended Citation
Baranova, Danielle Elizabeth, "Adaptation of vibrio cholerae O1 to protective, lipopolysaccharide-specific antibodies in the intestinal lumen" (2020). Legacy Theses & Dissertations (2009 - 2024). 2432.
https://scholarsarchive.library.albany.edu/legacy-etd/2432
C3_Video S2.avi (8565 kB)
C3_Video S3.avi (5032 kB)
C3_Video S4.avi (6202 kB)
C6_Appendix 1.xlsx (47 kB)
C6_Appendix 2.xlsx (458 kB)
C6_Appendix 3.xlsx (164 kB)
Included in
Immunology of Infectious Disease Commons, Microbiology Commons, Molecular Biology Commons