Date of Award
1-1-2019
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Biological Sciences
Content Description
1 online resource (xix, 320 pages) : color illustrations.
Dissertation/Thesis Chair
Marlene Belfort
Committee Members
Richard Cunningham, Kathleen McDonough, Robert Osuna, Sudha Chaturvedi
Keywords
crystal structure, inteins, metals, protein splicing, Eukaryotic cells, Protein precursors, Protein engineering, Pathogenic microorganisms, Microbial genomics
Subject Categories
Biochemistry | Bioinformatics | Biology
Abstract
Inteins are self-splicing elements that orchestrate the autocatalytic process of protein splicing, during which the intein excises itself from a host polypeptide. This multistep reaction involves a series of coordinated nucleophilic attacks and peptide bond rearrangements that remove the intein and reassemble the flanking halves, called exteins, to form the mature host protein. Some inteins are also mobile elements, and can spread to the same or ectopic sites using an internal homing endonuclease domain.
Recommended Citation
Schiraldi, Cathleen Maria, "Inteins from pathogenic microbes as regulatory elements and potential drug targets" (2019). Legacy Theses & Dissertations (2009 - 2024). 2373.
https://scholarsarchive.library.albany.edu/legacy-etd/2373
BMC_license_agreement.pdf (171 kB)
JBC_editorial_policies.pdf (116 kB)
PNAS_author_license.pdf (98 kB)
Included in
Biochemistry Commons, Bioinformatics Commons, Biology Commons