Date of Award
1-1-2019
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Chemistry
Content Description
1 online resource (xxii, 162 pages) : illustrations (some color)
Dissertation/Thesis Chair
Gerd U Flechsig
Committee Members
Alexander Shekhtman, Jan Halamek, Alan A Chen, Miroslav Fojta
Keywords
Cisplatin, DNA Self-assembled monolayers, Electrochemical Quartz Crystal Microbalance, Hexaammine ruthenium(III), Kinetic isotope effect, Viscoelasticity, Monomolecular films, DNA, Biosensors, Electrochemical sensors, Electrochemistry, Gold
Subject Categories
Chemistry
Abstract
Biosensors based on DNA self-assembled monolayers (SAMs) combined with electrochemical transducers have shown great potential to serve an important role in simple, accurate and inexpensive genetic analyses relevant to many fields. The most popularly adapted method in designing biosensing platforms is the self-assembly of 5’-alkylthiol-modified single stranded or double stranded DNA on gold surfaces followed by a passivation step using a diluent like mercaptohexanol (MCH). Since analytical performance (sensitivity, selectivity and stability) of such sensors is solely related to the probe surface architecture, methods to characterize and measure the surface density has gained a lot of interest among the scientific community.
Recommended Citation
Galagedera, Sarasi Kaushalya Kumari, "Study of small molecules with DNA monolayers on gold electrodes using electrochemical quartz crystal microbalance on the millisecond timescale" (2019). Legacy Theses & Dissertations (2009 - 2024). 2286.
https://scholarsarchive.library.albany.edu/legacy-etd/2286