Date of Award

1-1-2010

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College/School/Department

Department of Epidemiology and Biostatistics

Program

Epidemiology

Content Description

1 online resource (xiv, 236 pages) : illustrations (some color)

Dissertation/Thesis Chair

Louise-Anne McNutt

Committee Members

Howard Stratton, Jerry O Stern, Fred Moy, Christopher Miller

Keywords

abacavir, CVD, hepatotoxicity, HIV, recurrent events, tipranavir, HIV infections, Protease inhibitors, HIV-positive persons

Subject Categories

Epidemiology | Medical Sciences

Abstract

Dose-limiting adverse events associated with anti-retroviral therapy (ART) generally include gastro-intestinal (GI) issues such as vomiting and nausea. However, serious adverse events (SAEs) do occur, the most frequent of which include liver toxicities and renal impairment as well as recent evidence of cardio-vascular disease (CVD) risk.

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