Date of Award

1-1-2018

Language

English

Document Type

Master's Thesis

Degree Name

Master of Science (MS)

College/School/Department

Department of Biomedical Sciences

Content Description

1 online resource (ix, 61 pages) : illustrations (some color)

Dissertation/Thesis Chair

Magdia De Jesus

Committee Members

Magdia De Jesus, Richard Cole, Nicholas Mantis, Sudha Chaturvedi

Keywords

Candida albicans, disseminated Candidiasis, intestinal microbiome, Peyer's patches, Intestinal mucosa

Subject Categories

Immunology of Infectious Disease

Abstract

A murine model that established GI colonization of Candida albicans and eventual dissemination was identified to be lacking by Koh and others. Koh’s model specifically employed a tailored combination of neutropenia, intestinal damage, and microbiome dysbiosis that would allow C. albicans to gain an opportunistic advantage. His model provided new opportunities to study the details of C. albicans pathogenesis with a focus on the innate immune mechanisms responsible for controlling C. albicans within the intestinal mucosa. The long-term goal of this research project was to specifically study the factors associated with Candida albicans dissemination via the intestinal mucosa. The model used treatment with N-acetylcysteine (NAc), Dextran Sodium Sulfate (DSS), and an antibiotic cocktail that would allow for C. albicans to have an advantage upon uptake.

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