Date of Award
1-1-2018
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Chemistry
Content Description
1 online resource (ii, vii, 199 pages) : illustrations (some color)
Dissertation/Thesis Chair
Mehmet Yigit
Committee Members
Paul Toscano, Ken Halvorsen, Jia Sheng, Maksim Royzen
Keywords
Cancer, Detection, miRNA, Nanoparticles, siRNA, Biochemical markers, Tumor markers, MicroRNA, Nanobiotechnology, Nanomedicine, Fluorescence spectroscopy
Subject Categories
Chemistry
Abstract
The uniqueness and expression of miRNAs as biomarkers in certain cancers has the potential to radically alter the detection, and therefore the treatment, of the disease. Not only are current detection methods time consuming, and not sensitive enough for biomedical applications, but these small RNAs have yet to be fully utilized in treatment. By utilizing different nanomaterials we aimed to create novel nanodevices for the early, sensitive and specific detection of these biomarkers in a minimally invasive way and develop dual drug releasing nanoparticles, which are entirely controllable, to aid in the treatment of resistant cancer phenotypes.
Recommended Citation
Robertson, Neil M., "Chemically and biologically responsive nanoparticle systems for biomarker detection and combination cancer therapy" (2018). Legacy Theses & Dissertations (2009 - 2024). 2151.
https://scholarsarchive.library.albany.edu/legacy-etd/2151