Date of Award
1-1-2010
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Biomedical Sciences
Content Description
1 online resource (viii, 132 pages) : color illustrations.
Dissertation/Thesis Chair
Bruce John Herron
Committee Members
Xinxin Ding, Derek Symula, Douglas Conklin, Russell Ferland
Keywords
cell cycle, keratinocyte terminal differentiation, Stratifin, translational control, Skin, Genetic translation, Genetic regulation, Tumor suppressor proteins
Subject Categories
Genetics
Abstract
Three phenotypically similar mouse mutations that cause severe defects in skin terminal differentiation have been identified in stratifin (Sfn, also known as 14-3-3σ), I-Kappa Kinase alpha (IKKα) and Interleukin regulatory factor 6 (Irf6). IKKα and Irf6 have been proposed to regulate skin differentiation at the level of transcription. Sfn has been studied intensively as a negative cell cycle regulator during DNA damage response; however, its role in skin development has not been fully characterized.
Recommended Citation
Liu, Fang, "Stratifin is redundant in cell cycle regulation but essential for the translational control during skin development" (2010). Legacy Theses & Dissertations (2009 - 2024). 210.
https://scholarsarchive.library.albany.edu/legacy-etd/210