Isolation and characterization of RNA aptamers against glutamate ion channel receptors

Date of Award

1-1-2018

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College/School/Department

Department of Chemistry

Content Description

1 online resource (xv, 219 pages) : illustrations.

Dissertation/Thesis Chair

Li Niu

Committee Members

Jayanti Pande, Jia Sheng, Alexander Shekhtman, Alan Chen, Hua Shi

Keywords

RNA, Oligonucleotides, Neurotransmitter receptors, Glutamic acid, Introns

Subject Categories

Chemistry | Molecular Biology

Abstract

Ionotropic glutamate receptors (iGluRs) are ligand-gated transmembrane ion channels, and they mediate the majority of excitatory synaptic transmission in the central nervous system (CNS). iGluRs are divided into three subtypes, namely α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate and N-methyl-D-aspartate (NMDA) receptors. These receptors are essential for neuronal development and brain function. Over-activation or excessive activity of these receptors, however, has been linked to various neurological diseases, such as stroke, epilepsy and neuropathic pain. Inhibitors of these receptors are potential drug candidates for the treatment of these neurological diseases. Therefore, developing potent and selective inhibitors against these receptors is significant. Specifically, my thesis work has focused on developing ribonucleic acid (RNA) aptamers against AMPA and kainate receptors.

Comments

Requested ProQuest takedown; no end date

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