Date of Award
1-1-2017
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Chemistry
Content Description
1 online resource (ii, xii, 100 pages) : illustrations (some color)
Dissertation/Thesis Chair
Li Niu
Committee Members
Daniele Fabris, Jayanti Pande, Alexander Shekhtman, Ting Wang
Keywords
Electrophysiology, Patch clamp, Benzodiazepines, Glutamic acid, Neurotransmitter receptors
Subject Categories
Biochemistry | Physical Chemistry
Abstract
AMPA receptors are a subtype of the ionotropic glutamate receptor family. They are ligand-gated or glutamate-activated, transmembrane ion channels that mediate the majority of excitatory synaptic transmission in the central nervous system. AMPA receptors are essential for neuronal development and brain functions, including learning and memory. Over-activation of calcium permeable AMPA receptors has been linked to some neurological diseases such as stroke, Alzheimer’s disease and amyotrophic lateral sclerosis. Inhibitors of glutamate receptors are therefore drug candidates for the potential treatment of these neurological diseases. One of the most promising classes of AMPA receptor antagonists is 2,3-benzodiazepine derivatives, thought to be a group of noncompetitive inhibitors.
Recommended Citation
Wu, Yin-Shuo (Andrew), "A kinetic study of regulation of GluA1 homomeric and heteromeric AMPA receptors by 2,3-Benzodiazepines" (2017). Legacy Theses & Dissertations (2009 - 2024). 1978.
https://scholarsarchive.library.albany.edu/legacy-etd/1978