Development of paramagnetic NMR probes to study RNA-protein interactions

Author

Leah M. Seebald, University at Albany, State University of New YorkFollow

Date of Award

1-1-2017

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College/School/Department

Department of Chemistry

Content Description

1 online resource (xv, 140 pages) : illustrations.

Dissertation/Thesis Chair

Maksim Royzen

Committee Members

Alexander Shekhtman, John Welch, Marlene Belfort

Keywords

NCp7, NMR, PRE, RNA, Nuclear magnetic resonance, Paramagnetism, RNA-protein interactions, Nucleoproteins, HIV (Viruses)

Subject Categories

Chemistry

Abstract

This thesis describes the rational design of new probes for RNA-protein interaction studies by NMR. Two generations of transition metal ion based NMR probes have been made and tested with a proof-of-principle interaction between the HIV Nucleocapsid protein 7 and a model RNA pentanucleotide.

Comments

Requested ProQuest takedown; no end date

Recommended Citation

Seebald, Leah M., "Development of paramagnetic NMR probes to study RNA-protein interactions" (2017). Legacy Theses & Dissertations (2009 - 2024). 1943.
https://scholarsarchive.library.albany.edu/legacy-etd/1943