Date of Award

1-1-2010

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College/School/Department

Department of Environmental Health Sciences

Content Description

1 online resource (xvi, 272 pages) : illustrations (some color)

Dissertation/Thesis Chair

Patrick J Parsons

Committee Members

Kenneth Aldous, Kurunthachalam Kannan, Irina Birman, Jean-Philippe Weber

Keywords

Analytical Atomic Spectrometry, Arsenic, Biological Fluids, Clinical Method Development, Speciation analysis, Urine, Liquid chromatography, Urinalysis, Chromatography, Liquid, liquid chromatography

Subject Categories

Analytical Chemistry | Environmental Health | Toxicology

Abstract

Arsenic exists as many different chemical forms including inorganic, methylated and dietary species. The toxicity of these species varies: some are highly toxic and can cause adverse health effects in many parts of the body; others are considered relatively non-toxic. Monitoring arsenic exposure is usually accomplished by its direct measurement in biological fluids. Urine is the specimen of choice for assessing arsenic exposure, because of its short biological half-life in blood. There have been very few studies of arsenic species in blood, yet such research can provide valuable information on arsenic distribution and its metabolism in the body.

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