Date of Award

1-1-2017

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College/School/Department

Department of Nanoscale Science and Engineering

Program

Nanoscale Sciences

Content Description

1 online resource (iii, ix, 101 pages) : illustrations (some color)

Dissertation/Thesis Chair

Xinxin Ding

Committee Members

Thomas Begley, Michael Fasullo, J. Andres Melendez, Qing-Yu Zhang

Keywords

Bioactivation, Tobacco smoke, Cytochrome P-450, Biochemical markers, Tobacco use, Lungs

Subject Categories

Biology | Toxicology

Abstract

The overall goal of the research conducted in this dissertation is to determine the role of cytochrome (CYP) P450-mediated xenobiotic bioactivation in the development of tobacco smoke-induced lung toxicity. The central hypothesis of this work is that CYP-mediated bioactivation of specific tobacco smoke constituents is an important contributor to the generation of tobacco smoke-induced lung inflammation and injury. The specific aims are 1) to demonstrate that CYP-mediated metabolism contributes to the onset of lung inflammation following tobacco smoke inhalation; 2) to demonstrate that specific tobacco smoke constituents undergo CYP-mediated bioactivation in vivo; 3) to demonstrate that CYP-mediated bioactivation of tobacco smoke constituents contributes to the occurrence of DNA damage in vivo.

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