Spinal cord regeneration in xenopus laevis tadpoles

Date of Award

1-1-2010

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College/School/Department

Department of Biological Sciences

Content Description

1 online resource (x, 173 pages)

Dissertation/Thesis Chair

Ben G Szaro

Committee Members

John Schmidt, Sridar Chittur, Igor Kuznetsov

Keywords

metamorphosis, regeneration, spinal cord, xenopus, Spinal cord, Tadpoles

Subject Categories

Neuroscience and Neurobiology

Abstract

Adult mammals lack the ability to regenerate their central nervous system (CNS) after injury. However, lower vertebrates such as fish and some urodele amphibians, can regenerate their CNS throughout life. The anuran frog, Xenopus laevis, is capable of regenerating its spinal cord as a tadpole but loses the ability to do so as an adult. For my thesis, I proposed to examine the cell and molecular factors that play a role in transforming the regeneration permissive CNS of the tadpole into one that inhibits spinal cord regeneration after metamorphosis.

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