Date of Award

1-1-2016

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College/School/Department

Department of Nanoscale Science and Engineering

Program

Nanoscale Engineering

Content Description

1 online resource (xix, 211 pages) : illustrations (some color)

Dissertation/Thesis Chair

Magnus Bergkvist

Committee Members

Xinxin Ding, Benoit Boivin, Susan Sharfstein, Nadine Hempel

Keywords

Drug Delivery, Glycogen, Nanotechnology, Photodynamic Therapy, siRNA, Drug delivery systems, Dendrimers, Nanostructured materials, Small interfering RNA

Subject Categories

Biochemistry | Biomedical Engineering and Bioengineering | Pharmacy and Pharmaceutical Sciences

Abstract

The field of medicinal chemistry is ever expanding, designing and discovering new therapeutic strategies. Oftentimes, it is challenging for these therapeutics to undergo clinical translation due to ineffective administration or unwanted toxicity in vivo. As such, drug delivery vehicles are designed to overcome these hurdles, allowing for delivery to the site of action by improving biodistribution, protecting therapeutic cargo, and decreasing toxicity. The work presented here aims to investigate a naturally-derived carbohydrate nanodendrimer, enzymatically synthesized glycogen (ESG) for drug delivery. This nontoxic, highly-branched, glucose-based structure has interior void volumes to allow for cargo encapsulation as well as a large density of surface functionalities for chemical functionalization.

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