Date of Award
1-1-2016
Language
English
Document Type
Master's Thesis
Degree Name
Master of Science (MS)
College/School/Department
Department of Chemistry
Content Description
1 online resource (vi, 175 pages) : color illustrations
Dissertation/Thesis Chair
Alexander Shekhtman
Committee Members
Jayanti Pande
Keywords
Nuclear magnetic resonance spectroscopy, Proteins, Genetic disorders, Drugs, Drug targeting
Subject Categories
Biochemistry
Abstract
Different techniques have been developed over the years for the purpose of studying proteins and understanding their functions. Early techniques typically employed bioluminescence or fluorescence such such as the firefly protein luciferase and the jellyfish green fluorescent protein (GFP), respectively, to localize proteins within the cell. X-ray crystallography has also provided valuable structural details of many different proteins in vitro. Yet, nuclear magnetic resonance (NMR) spectroscopy offers the most realistic insight into proteins' physiologic structures and how proteins function in their native, cellular environments.
Recommended Citation
Dansereau, Stephen, "A survey of the current drug screening techniques to obtain rational design and study drug-target interactions" (2016). Legacy Theses & Dissertations (2009 - 2024). 1592.
https://scholarsarchive.library.albany.edu/legacy-etd/1592