Date of Award

1-1-2015

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College/School/Department

Department of Chemistry

Content Description

1 online resource (xiii, 107 pages) : color illustrations.

Dissertation/Thesis Chair

Igor K Lednev

Committee Members

Alexander Shekhtman, Maksim Royzen, Mehmet Yigit, Arcadius Krivoshein

Keywords

Amyloid Fibrils, Inclusion Bodies, Stability, Structure, Vibrational Spectroscopy, Amyloid, Vibrational spectra, Amyloidosis, Protein folding

Subject Categories

Analytical Chemistry | Biophysics | Chemistry

Abstract

Protein misfolding often leads to the formation of refractory protein aggregates like amyloid fibrils. These fibrils possess a highly ordered structure and are implicated in over 25 severe diseases including Alzheimer’s, Parkinson’s and prion diseases. This work was focused on understanding the morphology and conformation of amyloid fibrils and their stability after formation. The deconstruction of fibrils as well as other aggregates like inclusion bodies under mild conditions was also investigated using Archaeal chaperones.

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