Date of Award
1-1-2015
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Chemistry
Content Description
1 online resource (xiii, 107 pages) : color illustrations.
Dissertation/Thesis Chair
Igor K Lednev
Committee Members
Alexander Shekhtman, Maksim Royzen, Mehmet Yigit, Arcadius Krivoshein
Keywords
Amyloid Fibrils, Inclusion Bodies, Stability, Structure, Vibrational Spectroscopy, Amyloid, Vibrational spectra, Amyloidosis, Protein folding
Subject Categories
Analytical Chemistry | Biophysics | Chemistry
Abstract
Protein misfolding often leads to the formation of refractory protein aggregates like amyloid fibrils. These fibrils possess a highly ordered structure and are implicated in over 25 severe diseases including Alzheimer’s, Parkinson’s and prion diseases. This work was focused on understanding the morphology and conformation of amyloid fibrils and their stability after formation. The deconstruction of fibrils as well as other aggregates like inclusion bodies under mild conditions was also investigated using Archaeal chaperones.
Recommended Citation
Shanmugasundaram, Marudachalam, "Structure and stability of amyloid fibrils studied by advanced vibrational spectroscopy" (2015). Legacy Theses & Dissertations (2009 - 2024). 1505.
https://scholarsarchive.library.albany.edu/legacy-etd/1505