Date of Award

1-1-2009

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College/School/Department

Department of Biomedical Sciences

Content Description

1 electronic text (xi, 115 pages) : illustrations (some color)

Dissertation/Thesis Chair

Xinxin Ding

Committee Members

Lawrence Kaminsky, Erasmus Schneider, Michele Caggana, Derek Symula

Keywords

Acetaminophen, CYP2A5, Knock-out, Nicotine, Steroid Hormone, Biochemical toxicology, Cytochrome P-450, Drugs, Homeostasis, Mice, Steroid hormones

Subject Categories

Biochemistry | Genetics | Molecular Biology

Abstract

The central hypothesis is that CYP2A5 plays an important role in the metabolism of xenobiotic substrates, and in the toxicity induced by over-exposure to drugs, as well as in the metabolism of endogenous compounds and regulation of steroid hormone homeostasis. The specific aims are: 1) to generate and characterize a Cyp2a5-null mouse; 2) to determine the role of CYP2A5 in the systemic clearance of nicotine and cotinine; and 3) to explore the mechanisms underlying the resistance of the lateral nasal gland (LNG) of male Cyp2g1-null/Cyp2a5-low mouse and Cyp2a5-null mouse to acetaminophen (AP) toxicity.

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