Date of Award




Document Type

Master's Thesis

Degree Name

Master of Science (MS)


Department of Chemistry

Content Description

1 online resource (iv, 89 pages) : color illustrations.

Dissertation/Thesis Chair

Daniele Fabris


Ion mobility spectrometry-mass spectrometry, Nucleic Acids, Nucleic acids, Ion mobility spectroscopy, Mass spectrometry, DNA-ligand interactions, Ligand binding (Biochemistry)

Subject Categories

Analytical Chemistry | Biochemistry | Chemistry


Three-dimensional structures of biopolymers frequently dictate the biological role those molecules play. As such, investigation into structure of nucleic acids can provide important information pertaining to how those nucleic acids work. Many nucleic acid species, especially single-stranded RNA, fold into unique structures that allow them to function properly. Metals, and other cationic species, are often bound to the nucleic acid to make folding into the proper structure more favorable by neutralizing the negative charge on the nucleic acid imparted by the phosphate group. This investigation explores tertiary structure of nucleic acids that have been folded in the presence of ligands using ion mobility spectrometry-mass spectrometry (IMS-MS).