Date of Award
1-1-2014
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Biological Sciences
Content Description
1 online resource (xiv, 165 pages) : illustrations (some color)
Dissertation/Thesis Chair
Melinda Larsen
Committee Members
Benjamin Szaro, Gregory Lnenicka, Bulent Yener
Keywords
Cell-graph, Cleft formation, Computational Modeling, GGH Model, LIM Kinase, Salivary Gland, Morphogenesis, Branching processes, Submandibular gland
Subject Categories
Cell Biology | Computer Sciences | Developmental Biology
Abstract
Branching morphogenesis is a conserved mechanism of mammalian organ development (salivary glands, lungs, mammary glands, pancreas, kidney, etc.), and has been a classic topic of study for generations of developmental biologists. During the process of tissue formation, several cellular and molecular and protein signaling events occur at successive stages enabling proper formation of tissue shape and structure. In order to provide a comprehensive understanding of the process of branching morphogenesis, we need a systems level approach to integrate multifactorial information. My overall global hypothesis is that multiple mathematical modeling approaches can be utilized to extract crucial cellular and tissue level information, generating biological hypotheses which can guide us towards unraveling mechanistic details of cleft formation.
Recommended Citation
Ray, Shayoni, "Computational modeling-driven study of signaling pathway affecting cleft formation during submandibular salivary gland development" (2014). Legacy Theses & Dissertations (2009 - 2024). 1245.
https://scholarsarchive.library.albany.edu/legacy-etd/1245