Date of Award

1-1-2014

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College/School/Department

Department of Biological Sciences

Content Description

1 online resource (xvi, 222 pages) : illustrations (some color)

Dissertation/Thesis Chair

Melinda Larsen

Committee Members

Magnus Bergkvist, JoEllen Welsh, George Plopper, John Schmidt, Albert Millis

Keywords

compliance, differentiation, regenerative medicine, salivary gland, stiffness, tissue engineering, Submandibular gland, Morphogenesis, Branching processes, Mice

Subject Categories

Developmental Biology

Abstract

The embryonic mouse submandibular salivary gland (mSMG) is a classic model to study mechanochemical signals involved in morphogenesis and differentiation amongst multiple, interacting cell populations. Scaffold compliance is alters cellular phenotype, but little is known about the effects of compliance on organogenesis. The overall aim of this project was to demonstrate that the processes of salivary gland epithelial branching morphogenesis and differentiation require a compliant, in vivo-like environment and are disrupted outside of this range.

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