Date of Award

1-1-2014

Language

English

Document Type

Master's Thesis

Degree Name

Master of Science (MS)

College/School/Department

Department of Nanoscale Science and Engineering

Program

Nanoscale Engineering

Content Description

1 online resource (v, 89 pages) : color illustrations.

Dissertation/Thesis Chair

James Castracane

Committee Members

Nate Cady, Nadine Hempel, Hassaram Bakhru

Keywords

Biomarker, Ischemia, NGAL, Renal, Reperfusion, Transplant, Isolation perfusion (Physiology), Kidneys, Acid-base equilibrium

Subject Categories

Biochemistry | Biology | Biomedical Engineering and Bioengineering

Abstract

A shortage of viable kidneys available for transplantation exists today, as the number of individuals waiting for a kidney transplant continues to grow while the number of kidneys available each year for transplantation has remained stagnant. The development of technology that will allow for transplantation of organs that currently may be considered too damaged for transplant will provide access to a large number of donors who have experienced traumatic injury deaths resulting in loss of cardiac function. These potential donors account for the majority of all traumatic injury deaths in intensive care units, however their organs have experienced a degree of warm ischemia that renders the organs not viable for transplantation. The warm perfusion system developed by Breonics Inc., known as Exsanguinous Metabolic Support (EMS) provides the capability to restore oxidative metabolism in these organs, potentially reducing the impact of reperfusion injury compared to a cold preserved allograft and allowing for cellular repair mechanisms to take place during twenty-four hours of warm perfusion.

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