Date of Award
1-1-2014
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Biomedical Sciences
Content Description
1 online resource (xii, 200 pages) : color illustrations
Dissertation/Thesis Chair
Jonathan S Carp
Committee Members
Jonathan R Wolpaw, Xiang Yang Chen, Damian S Shin, Terence C Wagenknecht
Keywords
electromyography, external urethral sphincter, lower urinary tract, micturition, motoneurons, spinal cord injury, Urinary organs, Spinal cord
Subject Categories
Neuroscience and Neurobiology
Abstract
Lower urinary tract (LUT) dysfunction is a major problem for people with spinal cord injury (SCI). SCI impairs the reciprocal coordination of the two main LUT functional components: the bladder, a storage reservoir for urine; and the external urethral sphincter muscle (EUS), which regulates the passage of urine through the urethra. This impairment frequently results in detrusor-sphincter dyssynergia (DSD), a dangerous condition in which involuntary EUS contraction prevents voiding of urine from the bladder. Despite the critical role of the EUS during normal function and in DSD, studies of the contribution of SCI-induced EUS motoneuron abnormalities to EUS and LUT dysfunction are rare and this contribution remains poorly understood. This represents a major deficiency in the current understanding of DSD.
Recommended Citation
Lapallo, Brandon Keith, "Spinal transection changes external urethral sphincter muscle activity and motoneuron properties : implications for lower urinary tract function after spinal cord injury" (2014). Legacy Theses & Dissertations (2009 - 2024). 1171.
https://scholarsarchive.library.albany.edu/legacy-etd/1171