Date of Award
1-1-2013
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Environmental Health Sciences
Content Description
1 online resource (xii, 157 pages) : illustrations (some color)
Dissertation/Thesis Chair
Qing-Yu Zhang
Committee Members
Xinxin Ding, Robert Turesky, Laurence Kaminsky, Erasmus Schneider, David C Spink
Keywords
Cytochrome P450, Intestine, Intestine, Small, Cytochrome P-450, Xenobiotics, Mice as laboratory animals
Subject Categories
Pharmacology | Public Health | Toxicology
Abstract
The overall goal of this thesis work was to investigate the function and regulation of intestinal P450 enzymes (P450s). The central hypotheses are that 1) small intestinal (SI) P450s play an important role in the first-pass clearance of oral drugs and in bioactivation of chemicals that cause intestinal toxicity, 2) endogenous regulatory compounds produced by intestinal P450s are important for protection against chemical-induced colon inflammation, and 3) there is a cross talk between the liver and the SI that helps to maintain the overall xenobiotic-metabolism capacity of the digestive tract.
Recommended Citation
Zhu, Yi, "Function and regulation of intestinal p450 enzymes : insights from conditional cytochrome p450 reductase knockout mouse models" (2013). Legacy Theses & Dissertations (2009 - 2024). 1060.
https://scholarsarchive.library.albany.edu/legacy-etd/1060
Included in
Pharmacology Commons, Public Health Commons, Toxicology Commons