Date of Award

1-1-2013

Language

English

Document Type

Master's Thesis

Degree Name

Master of Science (MS)

College/School/Department

Department of Chemistry

Content Description

1 online resource (xi, 71 pages) : illustrations (some color)

Dissertation/Thesis Chair

Jayanti Pande

Committee Members

Alexander Shekhtman, Carla Theimer, Paul Toscano, Rabi Musah, Charles Scholes, John Welch

Keywords

cataract, congenital, crystallins, HGD, R76S, W156X, Cataract, Cataract in children

Subject Categories

Biochemistry | Chemistry

Abstract

Cataract is a vision impairment disease that leads to light scattering and opacity of the eye lens. It is recognized as the most prevalent cause of blindness. Most cataracts occur due to aging, but those that occur in childhood or in young adults are typically of genetic origin. In the young (developing) eye, post–surgical complications such as glaucoma are common after cataract surgery. Hence there is a great need to develop non-surgical intervention strategies for the treatment of cataract. Here, two cataract-associated mutants of human γD-crystallin (HGD): i) Arg76 to Ser (R76S) and ii) a truncation mutation at Trp156 (W156X or W156stop), were compared with the wild–type protein.

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