Date of Award
5-2014
Document Type
Honors Thesis
Degree Name
Bachelor of Science
Department
Nanoscale Science
Advisor/Committee Chair
Robert L. Brainard
Abstract
There is an unmet need for controlled, dynamic cell scaffolds that will generate 3-D monolayers of epithelial cells for medical research and tissue engineering. Here we describe a system that uses photoimageable and biocompatible HEMA-based hydrogel bilayers that self-assemble from 2-D substrates into 3-D tube-shaped structures. These structures are patterned on top of another layer that demonstrates an ability to anchor the assembled structure and control the direction and extent of selfassembly. Cell viability was determined by MTT assay which shows material components comparable with the positive control (80-110%). Finally, the masks used in the experiments herein were redesigned to improve ease of use, alignment and testability.
Recommended Citation
Brisbois, chase Austyn, "Bio Roll-Up: Self-Assembling Scaffolds For Tissue Engineering" (2014). Nanoscale Science & Engineering (discontinued with class year 2014). 6.
https://scholarsarchive.library.albany.edu/honorscollege_nano/6