Date of Award
5-2017
Document Type
Honors Thesis
Degree Name
Bachelor of Science
Department
Chemistry
Advisor/Committee Chair
Shaker Mousa
Committee Member
Mehdi Rajabi
Committee Member
Paul Toscano
Abstract
Angiogenesis is the formation of new blood vessels from preexisting blood vessels. Design and development of novel angiogenesis inhibitors has been validated as a target in several tumor types. Integrins are important ligands that play a critical role in the angiogenesis process, particularly blood formation and local release of vascular growth factors, and they are members of a family of cell surface receptors. Tetraiodothyroacetic acid (tetrac), a deaminated derivative of thyroid hormone T4, is a thyroid antagonist and blocks the actions of T3 and T4 with an interaction site that is located at or near the RGD recognition site identified on integrin αvβ3’s binding pocket. In this study, we synthesized novel mono- and di-amino tetrac analogs and then tested them for their anti-angiogenesis activity.
Recommended Citation
Adeyeye, Mary, "Design, Synthesis and Characterization of New Analogs of Tetraiodothyroacetic Acid (Tetrac) as Novel Angiogenesis Modulators and their Binding Studies with αvβ3 Integrin" (2017). Chemistry. 12.
https://scholarsarchive.library.albany.edu/honorscollege_chem/12