Date of Award

Spring 5-2017

Document Type

Honors Thesis

Degree Name

Bachelor of Science

Advisor/Committee Chair

Mehmet Yigit, Ph . D .

Major

Biology

Committee Member

Prashanth Rangan, Ph . D

Abstract

The treatment of numerous disease states has become increasingly more complex and challenging, even as we come out with new pharmacological and technological advancements. It is well known that cancer is not one disease, but many diseases that progress and present new challenges with each patient. With this we present a novel design which uses biorthogonal chemistry and magnetic nanoparticles (MNP’s) to create a drug delivery system with the capability to deliver two drugs that are released at two different time points under the direction of a single trigger. This innovative combination of multiple advancements will allow for the treatment of normally resistant cancer phenotypes by rewiring the cell with one treatment, and then inducing apoptosis with the next, sequentially killing the targeted cell. Our system allows for a controllable, finely tuned delivery that can be targeted and imaged using MRI with our active MNP’s. The system has been tested with release kinetics using two florescent probes, and then later in vitro to confirm efficient delivery of the payload. This simple, non-invasive treatment allows for a much easier and effective dual drug delivery system. It was shown using triple negative breast cancer cell lines to be more effective than current therapeutic treatments and enhance the efficiency of the drugs, when used synergistically.

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