ORCID
0000-0001-7515-2998
Date of Award
Fall 2024
Language
English
Embargo Period
12-3-2025
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Chemistry
Program
Chemistry
First Advisor
Alxander Shekhtman
Committee Members
Alexander Shekhtman, Igor Lednev, Li Niu, Maxim Royzen, Ravichadran Ramasamay
Keywords
DIAPH1, RAGE, RHO, DIABETES, CARDIOVASCULAR DISEASE, INFLAMMATION
Subject Categories
Chemistry
Abstract
DIAPH1 is diaphanous related formin which polymerizes actin into filaments and is important to cytoskeleton dynamics.[1, 2] The dysregulation and aberrant activation of DIAPH1 is known to cause deafness[3, 4] and clotting disorders,[5] and is recently implicated in the inflammatory responses associated with cardiovascular and diabetic pathology.[6-9] Despite this, activation of the full length structure and its regulation are poorly understood.[10-12] Therefore, the main objective of this dissertation is to explore the structural, autoinhibitory, and regulatory properties of DIAPH1 in the context of disease pathology. Herein, I show that DIAPH1 has a dynamic structure which is regulated through negative cooperativity, and describe the structural interactions with proteins involved in inflammatory responses.
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Theophall, Gregory G., "STRUCTURAL BIOLOGY OF DIAPHANOUS-1 AND ITS ROLE IN HUMAN PATHOLOGY" (2024). Electronic Theses & Dissertations (2024 - present). 97.
https://scholarsarchive.library.albany.edu/etd/97
Comments
There is a 1 year embargo on this dissertation