Circadian Modulation of Neurons and Astrocytes Controls Synaptic Plasticity in Hippocampal Area CA1

Authors

John P. McCauley, University at Albany, State University of New York
Maurice A. Petroccione, University at Albany, State University of New York
Lianna Y. D'Brant, University at Albany, State University of New York
Gabrielle C. Todd, University at Albany, State University of New York
Nurat Affinnih, University at Albany, State University of New York
Justin J. Wisnoski, University at Albany, State University of New York
Shergil Zahid, University at Albany, State University of New York
Swasti Shree, University at Albany, State University of New York
Alioscka A. Sousa, University of Sao Paulo, Brazil
Rose M. De Guzman, University at Albany, State University of New York
Rosanna Migliore, Institute of Biophysics
Alexey Brazhe, Moscow State Lomonosov University
Richard D. Leapman, National Institutes of Health
Alexander Khmaladze, University at Albany, State University of New York
Alexey Semyanov, Sechenyi First Moscow State Meical University
Damian G. Zuloaga, University at Albany, State University of New York
Michele Migliore, Institute of Biophysics
Annalisa Sccimemi, University at Albany, State University of New York

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Document Type

Article

Publication Date

10-2020

DOI

https://doi.org/10.1016/j.celrep.2020.108255

Abstract

Most animal species operate according to a 24-h period set by the suprachiasmatic nucleus (SCN) of the hypothalamus. The rhythmic activity of the SCN modulates hippocampal-dependent memory, but the molecular and cellular mechanisms that account for this effect remain largely unknown. Here, we identify cell-type-specific structural and functional changes that occur with circadian rhythmicity in neurons and astrocytes in hippocampal area CA1. Pyramidal neurons change the surface expression of NMDA receptors. Astrocytes change their proximity to synapses. Together, these phenomena alter glutamate clearance, receptor activation, and integration of temporally clustered excitatory synaptic inputs, ultimately shaping hippocampal-dependent learning in vivo. We identify corticosterone as a key contributor to changes in synaptic strength. These findings highlight important mechanisms through which neurons and astrocytes modify the molecular composition and structure of the synaptic environment, contribute to the local storage of information in the hippocampus, and alter the temporal dynamics of cognitive processing.

Comments

This is the Publisher’s PDF of the following article made available by Cell Reports: https://doi.org/10.1016/j.celrep.2020.108255

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.

Recommended Citation

McCauley, John P.; Petroccione, Maurice A.; D'Brant, Lianna Y.; Todd, Gabrielle C.; Affinnih, Nurat; Wisnoski, Justin J.; Zahid, Shergil; Shree, Swasti; Sousa, Alioscka A.; De Guzman, Rose M.; Migliore, Rosanna; Brazhe, Alexey; Leapman, Richard D.; Khmaladze, Alexander; Semyanov, Alexey; Zuloaga, Damian G.; Migliore, Michele; and Sccimemi, Annalisa, "Circadian Modulation of Neurons and Astrocytes Controls Synaptic Plasticity in Hippocampal Area CA1" (2020). Biological Sciences Faculty Scholarship. 39.
https://scholarsarchive.library.albany.edu/biology_fac_scholar/39