Date of Award
8-1-2022
Language
English
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
College/School/Department
Department of Chemistry
Content Description
1 online resource (xiii, 172 pages) : illustrations (some color)
Dissertation/Thesis Chair
Alan A Chen
Committee Members
Alexander Shektman, Mehmit Yigit, Gabrielle Fuchs, Michael Yeung
Keywords
Ion mobility mass spectrometry, Nucleic acids
Subject Categories
Analytical Chemistry | Biochemistry | Computational Chemistry
Abstract
Ion mobility spectrometry - mass spectrometry (IMS-MS) has potential for the investigation of structure and dynamics in large biopolymers, which will come to full fruition only with a firmer understanding of how to interpret the experimental data. Numerous studies have employed elements of nucleic acid (NA) secondary structure, such as duplexes and hairpins, to explore the relationships between structure, experimental conditions, and actual observations. When combined with molecular dynamics simulations (MDS), IMS-MS can be effectively employed to perform structural elucidation of biomolecules that are not readily amenable to established techniques employed for structural analysis.
Recommended Citation
D'Esposito, Rebecca, "An IMS-MS/MD workflow for determining higher order structure and dynamics of nucleic acids" (2022). Legacy Theses & Dissertations (2009 - 2024). 2884.
https://scholarsarchive.library.albany.edu/legacy-etd/2884