Date of Award

1-1-2020

Language

English

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

College/School/Department

Department of Biomedical Sciences

Content Description

1 online resource (xviii, 236 pages) : illustrations (some color)

Dissertation/Thesis Chair

Nicholas J Mantis

Committee Members

Kathleen McDonough, Joseph Wade, Todd Gray, Fitnat Yildiz

Keywords

Antibody, Cholera, Enteric, Immunity, Pathogen, Vibrio cholerae, Lipoprotein antibodies, Immunoglobulins, Intestinal absorption, Mice as laboratory animals

Subject Categories

Immunology of Infectious Disease | Microbiology | Molecular Biology

Abstract

The outer membrane (OM) of Gram-negative enteric pathogens like Vibrio cholerae is a barrier against host defense factors, as well as a sensor of physical and chemical stimuli that the bacteria encounter in the gastrointestinal tract. The OM is also the primary target of the mucosal immune response, which consists of secretory antibodies primarily directed against lipopolysaccharide (LPS). ZAC-3 is a monoclonal antibody (MAb) that targets the conserved core/lipid A region of LPS of the pandemic V. cholerae O1 serotype. In a neonatal mouse model, passively administered ZAC-3 IgG has been shown to reduce the ability of V. cholerae to colonize the intestinal epithelium.

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